DuraQuench™ IQ & IQ-SA -
DuraQuench™ IQ Moisturisation Complex
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Discover an innovative approach to effective moisturization through
Croda’s moisturizing complex, DuraQuench IQ. Its dual mechanism
optimizes skin moisturization by the formation of an intelligent structural layer on
the surface of the skin, and regulates water loss from
within by reinforcing the skin’s natural barrier.
Please also see DuraQuench IQ SA which is JSQI and Chinese INCI approved. There are no
statistical differences in performance between DuraQuench IQ SA
and DuraQuench IQ.
- Long lasting
more radiant skin
against the drying effects of soaps and detergents
improvement in skin dryness
and humidity responsive
- Improves inherent skin
- Delivers superior
moisturization via dual action technology
DuraQuench IQ is able to
significantly improve the visual signs of skin dryness as
demonstrated in the following Moisture Efficacy Test (MET). The results of the
study show that the inclusion of DuraQuench IQ in the formulation led to
a significant improvement in skin dryness versus the control
formulation on day 12 and day 14 of the study, as seen below.
Following the treatment
phase, panelists entered the regression phase where they stopped
applying the test formulations. The skin treated with DuraQuench
IQ remained significantly more moisturized than the skin treated
with the control formulation on days 1, 2 and 3 of the
Not only does DuraQuench IQ outperform the control at relieving
the visible signs of skin dryness, it performs at a significantly faster
rate throughout the treatment phase. DuraQuench IQ also significantly outperforms
the control during the regression phase with its ability to
maintain an improvement in the visual signs of skin dryness. This
shows that DuraQuench IQ imparts long lasting hydration of the skin
that continues even when DuraQuench IQ is no longer applied.
The results of the MET show that the DuraQuench IQ formulation is more
efficient at relieving the visual signs of skin dryness than the control.
Skin Barrier Function
DuraQuench IQ improves inherent skin barrier function,
which can be seen in the results of a facial MET. Panelists entered a 4 day dry
down phase, washing their faces with soap, while stopping the use of
all moisturizing products and any cosmetic products. Following this, the 14
day treatment phase consisted of applying the DuraQuench IQ and
control formulation to each side of the face, respectively, while continuing to
wash the faces with soap. This was followed by a 5 day regression phase
where panelists continued to wash their faces with soap without application of
the test moisturizing creams.
Transepidermal water loss
(TEWL) readings were taken on each side of the face on days 0
(baseline), 7 and 14 of the treatment phase, and on days 2 and 5 of the
regression phase. The results below show the comparative net change in TEWL to
baseline for DuraQuench IQ in comparison to the control. The
results for day 7 and day 14 show a significant difference in TEWL for the
DuraQuench IQ formulation in comparison to the control.
Adhesive D-Squame discs, stained with multiple stain solution prior to
analysis, were used to measure superficial skin dryness on days 0 (baseline), 7 and 14
of the treatment phase, and on days 2 and 5 of the regression phase. The results show a
significant difference between the DuraQuench IQ and control on day 14 of the treatment
phase and on day 2 of the regression phase.
In order to evaluate how DuraQuench IQ responds to
varying temperatures and humidities, a thin film of both the DuraQuench IQ and
control formulations were dried onto a porous skin substitute (Vitrocorneum). Samples
were analyzed using the water vapor transport rate (WVTR) method at 20°C, 32°C
and 40°C ( ±1.5°C) at 30%, 50% and 80% (± 5%RH ) relative
humidity respectively. (32°C represents skin temperature.)
The results of the WVTR show that DuraQuench IQ is able to regulate the
level of water that evaporates at varying levels of humidity as seen below. The
formulation with DuraQuench IQ reduced water loss significantly versus the control
formulation at 30% and 50% relative humidity at 20°C, 32°C and 40°C.
Results at 40°C shown below.
This data shows that DuraQuench IQ can impart temperature and
humidity responsive properties for optimized moisturization benefits. Water
vapor transport rate was significantly lower with DuraQuench IQ than the control
X-ray diffraction can be used to give an indication of the lipid
structure that an emulsion forms on the skin. Wide angle x-ray diffraction (WAXD)
provides information about the smaller structural units in a sample,
such as the lateral packing in a lamellar phase. Small angle x-ray
diffraction (SAXD) provides information about larger structural units in a
sample, such as the periodicity in a stack of bilayers (bilayer to bilayer
distance). In this study, the DuraQuench IQ and control formulations were
compared using WAXD and SAXD.
The results from the WAXD
show that the control sample with 1 hour drying at 32°C
has two peaks, one at 0.47nm (a) and one at 0.40nm (b). In comparison, the
DuraQuench IQ sample with 1 hour drying at 32°C has two prominent
peaks in a more tightly packed 0.42nm (c) and 0.38nm (d) orthorhombic
phase. This repeat distance is very similar to that of the natural skin
lipids, 0.41nm and 0.37nm. The lateral packing of membranes determines
permeability which explains why the residual phase from the DuraQuench IQ
sample was more effective at controlling TEWL than the control.
In order to evaluate consumer perception of DuraQuench IQ, a panel
study was carried out and 31 panelists were asked to apply a formulation with and
without 5% DuraQuench IQ to either side of their face respectively for 1 week.
Panelists were asked to complete a pre- and post- study questionnaire. The results of
the study show that 71% of panelists preferred the formulation containing DuraQuench
IQ. Panelists also observed a significant improvement in skin smoothness and skin
radiance versus the control formulation.
The significant increase in skin smoothness and radiance seen using the
DuraQuench IQ formulation can be linked to skin hydration as there is a correlation
between the level of skin hydration and the amount of light absorbed or scattered by
the skin. In dehydrated skin, an increased amount of light is scattered at the skin
surface due to the raised edges of corneocytes, whereas in hydrated skin, more light
penetrates into the deeper skin layers resulting in darker, more pinkish and more