Sederma is the first to have developed matrikines, extracellular matrix-derived peptides, which are exact replicas of natural skin matrikines*. They act like cell messengers able to regulate the sequence of events required for skin repair (wound healing).
Matrikine peptide is recognised by a cell membrane receptor and binds to the receptor. Their biomimetic action triggers intracellular metabolisms that:
* Matrikine is a technical term proposed by Professor Maquart describing oligo-peptides and protein fragments that are generated during the macromolecule breakdown process (phase one). Some of the fragments thus generated possess stimulating and signalling activity in a feedback loop, initiating the repair process of the tissue matrix, hence the name. These peptide fragments participate in the wound healing as natural, non-toxic, locally acting, highly potent messengers.
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