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Best known active ingredients for ageing skin: The Matrixyl® range

Matrixyl®, this name sounds familiar to you, doesn't it? For sure! It is the name of one of the best known anti-ageing active ingredients. It is one of the rare ingredient names that is known by end-users and which benefits from their recognition.

Matrikine peptides act from the inside to provide long term effects against skin ageing. Sederma is the first to have developed matrikines, extracellular matrix-derived peptides, which are exact replicas of natural skin matrikines*. They act like cell messengers able to regulate the sequence of events required for skin repair (wound healing).

Matrikine peptide is recognised by a cell membrane receptor and binds to the receptor. Their biomimetic action triggers intracellular metabolisms that:

  • Promote tissue repair
  • Participate in wound healing
  • Stimulate macromolecule synthesis


* Matrikine is a technical term proposed by Professor Maquart describing oligo-peptides and protein fragments that are generated during the macromolecule breakdown process (phase one). Some of the fragments thus generated possess stimulating and signalling activity in a feedback loop, initiating the repair process of the tissue matrix, hence the name. These peptide fragments participate in the wound healing as natural, non-toxic, locally acting, highly potent messengers.


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Matrixyl Inside logo for anti-ageing active peptides product range,  clear blue diamond-shaped on the navy blue background

The Matrixyl Inside® Logo


The Matrixyl® range is known worldwide, its name being synonymous with efficacy and reliability in fighting ageing signs. So, claim “Matrixyl Inside®” on your products! 

Sederma's won the 25 Years of Innovation Award during 25th edition of in-cosmetics which recognises the product that has had the greatest impact on the Personal Care ingredients market in the last quarter-century.

Matrixyl 25 years of innovation award
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The Matrixyl® range

Matrixyl® 3000

Matrixyl® 3000

Matrikines anti-wrinkle complex helps reverse the chronological ageing as attested by the regulation of senescence markers and reduce the cutaneous photo damage by restructuring the fragile network.....

Matrixyl® synthe’6®

Matrixyl® synthe’6®

Powerful anti–wrinkle peptide acting on 6 skin–rebuilding essentials and tested with success on the forehead. Matrixyl® has received the in-cosmetics 25 years of Innovation Award in 2015.

Matrixyl® Morphomics®

Matrixyl® Morphomics®

A new member of the Matrixyl Inside® range constitutes an unprecedented way of combating wrinkles especially vertical lines that give the face a sad expression Issued from a new approach in.....

Get in touch to learn more about the Matrixyl® range